Selecting Optimal Animal Models to Investigate Environmental Toxicology

Male reproductive toxicology: comparison of the human to animal models.

The human male is of relatively low fertility and thus may be at greater risk from reproductive toxicants than are males of the common laboratory animal model species. Lack of knowledge of the physiological differences that contribute to interspecies variation between man and animals can prevent the effective application of animal data to the assessment of human reproductive risk. Evaluation of...

Animal Models to Investigate the Pathogenesis of Rheumatic Heart Disease

Rheumatic fever (RF) and rheumatic heart disease (RHD) are sequelae of group A streptococcal (GAS) infection. Although an autoimmune process has long been considered to be responsible for the initiation of RF/RHD, it is only in the last few decades that the mechanisms involved in the pathogenesis of the inflammatory condition have been unraveled partly due to experimentation on animal models. R...

Animal toxicology

As a number of reviews on different aspects of the toxicology of the PCBs have been written recently (1-4) no effort has been made in this report to give a complete outline of the animal toxicology. The material summarized in this report consists predominantly of more recently published information on toxic effects of PCBs in mammals and experimental studies in birds. Since Nelson et al. (3) di...

[Environmental toxicology].

Transgenic animal models in toxicology: historical perspectives and future outlook.

Transgenic animal models are powerful tools for developing a more detailed understanding on the roles of specific genes in biological pathways and systems. Applications of these models have been made within the field of toxicology, most notably for the screening of mutagenic and carcinogenic potential and for the characterization of toxic mechanisms of action. It has long been a goal of researc...